Transcriptional Control Of Cell Growth THE E2F GENE FAMILY (Current Topics in Microbiology & Immunology) by Peggy J Farnham

Cover of: Transcriptional Control Of Cell Growth | Peggy J Farnham

Published by SPRINGER-VERLAG .

Written in English

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Subjects:

  • Cellular biology,
  • Genetics (non-medical),
  • General,
  • Life Sciences - Biology - General,
  • Immunology,
  • Microbiology (General),
  • Medical / Nursing,
  • Science/Mathematics

Book details

The Physical Object
FormatHardcover
Number of Pages141
ID Numbers
Open LibraryOL12777246M
ISBN 103540601139
ISBN 109783540601135

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An important control point in this balance occurs in the G, phase of the cell cycle. Transcriptional Control of Cell Growth The E2F Gene Family. Editors: Farnham, Peggy (Ed.) Free Preview.

Buy this book eB08 € price for Spain (gross) Buy eBook ISBN ; Digitally watermarked, DRM-free. Overall, although the breadth of this book is enormous, there are certain minor but insightful aspects of cell division and growth, such as the phenomenon of gene amplification, transcriptional dysregulation in tumour cells and the role of the MPM-2 phosphoepitope in mitosis, that have been : Inez Vincent.

Transcriptional Control of Cell Growth: The E2F Gene Family (Current Topics in Microbiology and Immunology) [Peggy J. Farnham, Gregorio Escalante] on *FREE* shipping on qualifying offers. It is of critical importance to maintain an appropriate balance between proliferation and quiescence or differentiation through­ out the lifespan of all by: An important control point in this balance occurs in the G, phase of the cell cycle.

On the basis of environmental cues a cell in G, must decide whether to continue through the proliferative cycle and enter S phase (where DNA replication occurs) or to exit from the proliferative cycle into a nonreplicating state.

GRF-INTERACTING FACTORs (GIF1/2/3), a group of transcriptional co-activators, interact with Growth-Regulating Factors (GRFs) to Transcriptional Control Of Cell Growth book leaf, flower, and root development by regulating cell.

Cancer and Transcriptional Control. Many transcription factors, especially some that are proto-oncogenes or tumor suppressors, help regulate the cell cycle and, as such, determine how large a cell will get and when it can divide into two daughter cells.

Online shopping from a great selection at Books Store. Global transcriptional and epigenomic analyses in diverse cell types reveal that the primary action of Myc is to up- and downregulate transcription of distinct groups of genes, rather than to.

Transcriptional control of cell growth. Berlin ; New York: Springer, © (OCoLC) Material Type: Internet resource: Document Type: Book, Internet Resource: All Authors / Contributors: P J Farnham. Transcription control factors promote or prevent RNA polymerase binding.

Various trans‐acting factors (proteins) bind at specific cis‐acting factors can bind upstream of the promoter. Other factors bind to enhancer sequences and the chromatin folds to allow the enhancer‐binding factors to bind to the proteins at the promoter region or at the upstream.

In this review, we will briefly discuss progress in our understanding of a transcriptional control of T-cell development with special focus on the early commitment to the αβ T lineage, the helper versus cytotoxic lineage choice in the thymus and the differentiation of CD4 + T cells into T h 1 and T h 2 by:   Transcriptional control of a plant stem cell niche.

Busch W(1), Miotk A, Ariel FD, Zhao Z, Forner J, Daum G, Suzaki T, Schuster C, Schultheiss SJ, Leibfried A, Haubeiss S, Ha N, Chan RL, Lohmann JU.

Author information: (1)AG Lohmann, Max Planck Institute for Developmental Biology, D Tübingen, by:   Other cellular processes controlled by Myc and its target genes, such as nucleotide and energy metabolism, mitochondrial biomass, ribosome biogenesis, or cell growth/size 3,16,17, may feed back on general transcriptional activ29 (Fig.

4b): these feedback mechanisms are highly conserved, pre-date Myc in evolution and rely in part on Cited by:   The cambium and procambium generate the majority of biomass in vascular plants. These meristems constitute a bifacial stem cell population from which xylem and phloem are specified on opposing sides by positional signals.

The PHLOEM Transcriptional Control Of Cell Growth book WITH XYLEM (PXY) receptor kinase promotes vascular cell division and organization. However, how Cited by: 1. PDF | OnKristian Helin and others published Transcriptional control of cell growth: The E2F gene family: Edited by P.J.

Farnham; Springer, Berlin-Heidelberg-New York, vi + Author: Kristian Helin. Get this from a library. Transcriptional control of cell growth: the E2F gene family. [Peggy J Farnham;].

Furthermore, ectopic expression of Id3 in pro-B cells results in the rapid loss of cell viability, suggesting that the control of progenitor-cell growth and survival is an essential function of E2A in early B-cell development. Transcriptional control of plasma-cell differentiation Suppression of the terminal differentiation program by Bcl6 Cited by: Cancer and Gene Regulation Cancer is not a single disease but includes many different diseases.

In cancer cells, mutations modify cell-cycle control and cells don’t stop growing as they normally would. Mutations can also alter the growth rate or the Author: Lisa Bartee, Walter Shriner, Catherine Creech. Different post-transcriptional mechanisms have been associated with gene expression control, leading to complex transcriptional signatures in cancer.

The mechanisms presented in this chapter constitute fine regulators of gene expression which influence multiple and highly relevant pathways in cancer development (summarized in Figure 1).Author: Carlos DeOcesano-Pereira, Fernando Janczur Velloso, Ana ClaudiaOliveira Carreira, Carolina Simões Pi.

Cell division is a highly coordinated process. In the last decades, many plant cell cycle regulators have been identified. Strikingly, only a few transcriptional regulators are known, although a significant amount of the genome is transcribed in a cell cycle phase-dependent by:   OBP4 Is Expressed Preferentially in Differentiating Cells.

In order to identify novel transcriptional regulators that control cell growth in Arabidopsis (Arabidopsis thaliana), we have ranked about 2, entries present in the plant transcription factor database (PlnTFDB; Pérez-Rodríguez et al., ) for their likelihood to be involved in cell by: The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression.

In particular, the development of recombinant DNA techniques that began in the s provided. The growth of a cell or tissue involves complex interactions between genes, metabolism, nutrition and hormones. Until recently, separate lines of investigation have concentrated in isolated sections of each of the many independent levels of growth control; the interactions within and between the diverse pathways that affect growth and size at the Cited by: This is because oncogenes can alter transcriptional activity, stability, or protein translation of another gene that directly or indirectly controls cell growth.

An example of an oncogene involved in cancer is a protein called myc. Myc is a transcription factor that is aberrantly activated in Burkett’s Lymphoma, a cancer of the lymph system.

The generation of B-lymphocytes from hematopoietic stem cells is controlled by multiple transcription factors regulating distinct developmental aspects.

Ikaros and PU.1 act in parallel pathways to control the development of lymphoid progenitors in part by regulating the expression of essential signaling receptors (Flt3, c-Kit, and IL-7Rα).

The generation of the earliest B cell. A similar mechanism operates in the control of globin mRNA translation. The production of heme and of globin must be closely coordinated, because hemoglobin contains exactly one heme and two each of the α‐ and β‐globins. The major mRNAs in the developing red blood cell are those for the globin proteins.

Request PDF | Transcriptional Control of the Plant Cell Cycle | Progression through the eukaryotic cell cycle is driven and controlled by interlocked oscillating mechanisms, including reversible Author: Peter Doerner.

The generation of B-lymphocytes from hematopoietic stem cells is controlled by multiple transcription factors regulating distinct developmental aspects. Ikaros and PU.1 act in parallel pathways to control the development of lymphoid progenitors in part by regulating the expression of essential signaling receptors (Flt3, c-Kit, and IL-7Rα).

The generation of the earliest B cell Cited by: As with the epigenetic and transcriptional stages of processing, this post-transcriptional step can also be regulated to control gene expression in the cell. If the RNA is not processed, shuttled, or translated, then no protein will be synthesized.

RNA Splicing, the First Stage of Post-transcriptional Control. Each cellular distinction within the human body can be traced directly to transcriptional regulation, or differential use of the genome. Factors ranging from the course of progression during early stages of development, to environmental response under a myriad of conditions, are mechanisms encompassed by the field of transcriptional control.

Growth processes, governed by complex genetic networks in a coordinated manner, are determining factors for numerous crop traits. Many components of these networks, described in Arabidopsis and to a lesser extent in crops, enhance organ growth when perturbed. However, translating our understanding of plant growth into crop improvement has been very by:   Transcriptional regulation is fundamentally important for the progression of tissue stem cells through different stages of development and differentiation.

Mammalian skin epidermis is an excellent Cited by: 3. Figure In Drosophila melanogaster, the sex is determined by a series of splicing events in sex determination genes on a cell-by-cell basis without any involvement of sex hormones (which circulate throughout the entire body).The primary sex-determination gene is Sex lethal (Sxl), which is transcribed only when the X/A ratio (the X chromosome-to-autosome ratio) equals or.

This is because oncogenes can alter transcriptional activity, stability, or protein translation of another gene that directly or indirectly controls cell growth.

An example of an oncogene involved in cancer is a protein called myc. Myc is a transcription factor that is aberrantly activated in Burkett’s Lymphoma, a cancer of the lymph system.

In the root meristem, the quiescent center (QC) is surrounded by stem cells, which in turn generate the different cell types of the root. QC cells rarely divide under normal conditions but can replenish damaged stem cells. In the proximal meristem, the daughters of stem cells, which are referred to as transit-amplifying cells, undergo additional rounds of cell division prior Cited by:   The GOLVEN (GLV)/ROOT GROWTH FACTORS/CLE-Like small signaling peptide family is encoded by 11 genes in Arabidopsis (Arabidopsis thaliana).

Some of them have already been shown to control root meristem maintenance, auxin fluxes, and gravitropic responses. As a basis for the detailed analysis of their function, we determined the expression.

Molecular Cell Biology Lodish 8th Edition Pdf Free. Molecular Cell Biology Lodish 8th Edition Biology is a science fundamentally different from physics or chemistry, which deals with unchanging properties of matter that can be described by mathematical equations.

Biological systems, of course, follow the rules of chemistry and physics, but biology is a historical science. The importance of transcriptional regulation is illustrated by the correlation of expression of specific classes of genes with related biological processes occurring at specific stages of secondary growth, including cell division, cell expansion, and cell by: Proto-oncogenes are necessary for the normal control of cell growth and division.

If a particular operon encodes enzymes for making an essential amino acid and is regulated like the trp operon, then the repressor is active in the absence of the amino acid. E2F and DP family proteins are evolutionally conserved transcription factors among higher eukaryotes.

E2F and DP proteins typically form a heterodimeric complex, which controls cell proliferation by regulating expression of growth-related genes. In addition, E2F family proteins have roles in various cellular events that require the expression of context-specific : Hideyuki Komori, Ritsuko Iwanaga, Andrew P.

Bradford, Keigo Araki, Kiyoshi Ohtani. Medicago sativa L. is a tetraploid perennial forage legume of great agronomical interest. The increasing need for its use under water-deficit conditions as well as low-input systems demands further improvement of its drought tolerance.

On the other hand, Medicagoarborea L. is a perennial leguminous shrub, which is knownas a drought-tolerant species. In the present Cited by: 1.Transcriptional control defines regulatory events operative both developmentally and for support of bone tissue-specific properties.

This review focuses on components of transcriptional regulation that function in growth control during osteoblast proliferation and those that postproliferatively contribute to maturation of the bone by: In transcriptional control in eukaryotic cells A. a different combination of DNA binding proteins (transcriptional factors) may regulate the activity of a particular gene.

B. enhancers may be involved in the promotion as well as regulation of gene transcription. C. the control may be due to the phosphorylation of transcriptional factors by a.

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